Paclitaxel产品信息

产品名称：Paclitaxel

化学名：N-BENZYL-BETA-PHENYLISOSERINE ESTER

CAS No： 33069-62-4

分子式：C47H51NO14

分子量：853.92

纯度：99%

溶解度：Soluble to 25 mM in ethanol and to 100 mM in DMSO with gentle warming

保存：2-8°C

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货号：abs810020

规格： 大包装询价

库存：现货

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生物活性：

Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2cells, triggering apoptosis.

It selectively inhibits the proliferation of human endothelial cells (ECs) at ultra low concentrations (0.1-100 pM), while it inhibits non-endothelial type human cells at 10(4) - to 10(5) -fold higher concentrations, with IC50 = 1-10 nM. The selectivity of paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to paclitaxel at ultra low concentrations. They are inhibited by higher concentrations of paclitaxel with IC50 = 1-10 nM. Inhibition of human ECs by paclitaxel at ultra low concentrations does not affect the cellular microtubule structure. Paclitaxel blocks cells in G2-M, and this may result in a schedule-dependent effect on paclitaxel cytotoxicity.

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参考文献:

1.Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Jordan, A., et al.

Med. Res. Rev. 18, 259-296, (1998)

2.Targeting microtubules for cancer chemotherapy Zhou J, and Giannakakou P. Curr. Med. Chem.

Anticancer Agents 5, 65-71, (2005)

3.Microtubule-stabilizing natural products as promising cancer therapeutics Gallagher BM Jr. Curr. Med.

Chem. 14, 2959-2967, (2007)

4.Taxanes, microtubules and chemoresistant breast cancer McGrogan BT, et al. Biochim. Biophys. Acta

1785, 96-132, (2008)

5.Extensive Crosstalk Between O-GlcNAcylation And Phosphorylation Regulates Cytokinesis. Wang, Z.,

et al. Sci. Signal. 3, ra2, (2010)

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Research Use only 试验室研究用