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U0126

简要描述:U0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM).

  • 产品型号:abs810003
  • 厂商性质:生产厂家
  • 更新时间:2024-07-07
  • 访  问  量:1024

详细介绍

品牌absin纯度>98%
规格5mg;10mg;25mg;50mg;100mg供货周期现货
应用领域医疗卫生,化工,生物产业,制药,综合

描述:

U0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM). It is known that U-0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.

纯度:

>98%

储存/保存方法:

Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

温馨提示:本产品仅作科研实验使用,不支持临床等研究

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